Imipramine (Tofranil)
$0.50
Tofranil contains Imipramine and treats depression, and is also used for bedwetting in children and some anxiety conditions.
Drug Information
13 reviews for Imipramine (Tofranil)
Tofranil contains Imipramine.
Imipramine was one of the first antidepressants ever made. It is a tricyclic antidepressant used for depression and, in children, for bedwetting.
What is it used for?
- Depression
- Bedwetting in children aged 6 and over (short-term)
- Panic disorder (off-label)
How does it work?
Imipramine raises the levels of serotonin and noradrenaline in the brain, which improves mood. It also has effects on the bladder that help with bedwetting.
This information is written in simple words to help you understand this product. It does not replace advice from your doctor or pharmacist.
Read these points before you start. If any of them apply to you, talk to your doctor or pharmacist first.
- Antidepressants can, rarely, cause thoughts of self-harm or suicide, especially in people under 25 and in the first few weeks. Tell someone close to you that you are taking it and ask them to tell you if they notice changes in your mood or behaviour.
- Do not take it with, or within 2 weeks of, an MAOI antidepressant (such as phenelzine or selegiline), or with linezolid or methylene blue.
- Taking it with other medicines that raise serotonin (other antidepressants, tramadol, triptans for migraine, lithium, St John's wort) can cause serotonin syndrome.
- It can raise the risk of bleeding, especially with aspirin, ibuprofen, naproxen or blood thinners.
- Tell your doctor if you have epilepsy, bipolar disorder or mania, glaucoma, heart problems, liver or kidney problems, or diabetes.
- Do not stop taking it suddenly. This can cause withdrawal symptoms like dizziness, electric-shock feelings, bad dreams and irritability. Your doctor will lower the dose slowly.
- It may make you sleepy or dizzy. Do not drive until you know how it affects you, and avoid alcohol.
- Tell your doctor if you are pregnant, planning a pregnancy or breastfeeding.
- Do not take it if you have recently had a heart attack or have heart rhythm problems. Tell your doctor about any heart disease.
- Tell your doctor if you have glaucoma, trouble passing urine, an enlarged prostate, constipation, an overactive thyroid or porphyria.
- An overdose can be very dangerous. Keep it out of the reach of children and others at risk.
- Tell your doctor or pharmacist about every other medicine, vitamin or herbal product you use.
- Keep this product out of the reach and sight of children.
Like all medicines, Tofranil can cause side effects, but not everybody gets them.
Common side effects
- Feeling sick (nausea), especially in the first 1 to 2 weeks
- Headache
- Trouble sleeping or feeling sleepy
- Sweating
- Dry mouth
- Lower sex drive, or trouble reaching orgasm or getting an erection
- Constipation
- Blurred vision
- Dizziness when standing up
- Weight gain
These are usually mild and often get better as your body gets used to it. Tell your doctor if they bother you or do not go away.
Stop using it and get medical help straight away if you notice:
- Thoughts of harming yourself or ending your life
- Feeling very high, overexcited or reckless (mania)
- Fever, sweating, shaking, muscle twitching, fast heartbeat and confusion (possible serotonin syndrome)
- A fit (seizure)
- Unusual bleeding or bruising, or black stools
- Confusion, headache and weakness, especially in older people (low sodium)
- A fast, pounding or uneven heartbeat, or fainting
- Being unable to pass urine
- Eye pain with blurred vision and red eye
This is not a complete list. If you notice anything unusual, ask your doctor or pharmacist.
- For depression, take it once a day at bedtime or in divided doses. A common adult dose is 75 mg to 150 mg a day.
- For bedwetting, children take it 1 hour before bedtime. The dose depends on age.
- Swallow the tablet with water, with or without food.
If you miss a dose: Take it as soon as you remember, unless it is nearly time for your next dose. Never take two doses at once.
If you use too much: Contact your doctor, a poison control centre or your local emergency number straight away, even if you feel fine. Take the pack with you.
How to store it: Keep it in its original pack at room temperature (below 25°C / 77°F), away from heat, damp and direct sunlight. Do not use it after the expiry date.
- QHow long does Tofranil take to work?
- A
Some people notice better sleep or energy in 1 to 2 weeks, but it usually takes 4 to 6 weeks to feel the full benefit on mood. Keep taking it even if you do not feel different straight away.
- QHow long will I need to take Tofranil?
- A
Most people take it for at least 6 months after they feel better, to stop the depression or anxiety coming back. Your doctor will review this with you.
- QCan I drink alcohol with Tofranil?
- A
It is best to avoid alcohol. It can make you more drowsy and can make depression and anxiety worse.
- QIs Tofranil addictive?
- A
No, antidepressants are not addictive. But stopping suddenly can cause withdrawal-like symptoms, so always reduce slowly with your doctor.

Aiko Anderson –
The team kept me updated on my order status. Finding the right item took very little time. Pleased with the whole thing.
Tara Gonzalez –
Found what I needed on this site without any trouble. Support was friendly and cleared up my doubt quickly. I compared a few sites and this one had the better price.
Lucas Nowak –
Picked up my Tofranil from this site and I am glad I did. I checked everything against my order and it was all correct. Communication was good throughout the order. The seals were intact and everything looked fresh. Five stars from me.
Hannah Murphy –
I was a little nervous about ordering Tofranil online, but it turned out fine. Everything was in order when I opened the box.
Leila Rodriguez –
Placed an order for Imipramine and it was handled well. The steps at checkout were easy to follow. The quality looked good to me. I would recommend this site to friends and family.
Aditya Traore –
I was a bit unsure at first, but ordering here worked out fine. Creating an account and ordering was painless. It came in a reasonable amount of time. It was wrapped well enough that I had no worry about damage.
Viktor Ahmed –
I placed an order last week and it was handled well. The cost was clearly shown before I paid, so no nasty surprises.
Amelia Moreau –
I needed to place an order in a hurry and this site made it easy. No complaints about the product. It was affordable and the total at checkout matched what I expected. The outer box was discreet and the inside was well arranged.
Arthur Carter –
Just got my order and everything went well. I got an order confirmation right away and updates after that. The packing was discreet and tidy.
Neha Allen –
Wanted to share my experience with this order. Packaging was clean and professional. The Tofranil I ordered showed up right when they said it would.
Andres Torres –
Quick review of my recent order. It arrived on time, just as I expected. I reached out with a small query and it was sorted straight away. Thanks for making Tofranil so easy to order.
Yasmin Jimenez –
My order went through without any problems. The parcel arrived a day or two sooner than I figured. Besides that, the right item came, and the label matched my order.
Riley Cruz –
For the price, I could not ask for more. The Tofranil I got looked just like the listing. Everything inside was snug and protected.