Pioglitazone + Metformin (Actoplus Met)
$0.96
Actoplus Met combines Pioglitazone and Metformin to lower blood sugar in type 2 diabetes using two different actions in one tablet.
Drug Information
5 reviews for Pioglitazone + Metformin (Actoplus Met)
Actoplus Met combines two diabetes medicines in one tablet: pioglitazone and metformin. It is used when one medicine alone has not controlled blood sugar well enough.
What is it used for?
- Type 2 diabetes in adults
How does it work?
Pioglitazone helps the body's cells respond better to insulin. Metformin reduces the sugar made by the liver. Together they lower blood sugar in two ways.
This information is written in simple words to help you understand this product. It does not replace advice from your doctor or pharmacist.
Read these points before you start. If any of them apply to you, talk to your doctor or pharmacist first.
- This medicine works best together with healthy eating, regular activity and keeping a healthy weight.
- It is for type 2 diabetes. It is not a replacement for insulin in type 1 diabetes.
- Tell your doctor if you have kidney, liver or heart problems.
- Tell your doctor if you are pregnant, planning a pregnancy or breastfeeding. Insulin is often used instead during pregnancy.
- Alcohol can affect your blood sugar. Drink only small amounts and never on an empty stomach.
- Learn the signs of low blood sugar (shaking, sweating, hunger, fast heartbeat, confusion) and keep sugary sweets or glucose tablets with you.
- Do not take it if you have heart failure. It can cause fluid build-up and make heart failure worse.
- Do not take it if you have or have had bladder cancer, or have blood in your urine that has not been checked.
- Tell your doctor if you have liver disease or eye problems (macular oedema).
- It may raise the risk of broken bones, especially in women.
- In women who do not ovulate, it can restart ovulation and raise the chance of pregnancy.
- The metformin in this tablet can rarely cause lactic acidosis. Stop it and tell your doctor if you are very sick with vomiting or diarrhoea, and tell your doctor about any kidney problems or heavy drinking.
- Tell your doctor or pharmacist about every other medicine, vitamin or herbal product you use.
- Keep this product out of the reach and sight of children.
Like all medicines, Actoplus Met can cause side effects, but not everybody gets them.
Common side effects
- Weight gain
- Swelling of the ankles or feet
- Headache
- Cold-like symptoms
- Diarrhoea or stomach upset
These are usually mild and often get better as your body gets used to it. Tell your doctor if they bother you or do not go away.
Stop using it and get medical help straight away if you notice:
- Signs of very low blood sugar that do not get better after eating sugar: confusion, drowsiness, fits or passing out
- Signs of an allergic reaction, such as swelling of the face or lips, a severe rash, or trouble breathing
- Quick weight gain, swelling and breathlessness (possible heart failure)
- Blood in your urine or pain when passing urine
- Yellowing of the skin or eyes, dark urine
- Fast, deep breathing, severe muscle or stomach pain, feeling very cold or drowsy (possible lactic acidosis)
This is not a complete list. If you notice anything unusual, ask your doctor or pharmacist.
- Take it with meals, usually once or twice a day.
- Swallow the tablet whole with water.
- Your doctor will choose the dose based on the medicines you already take.
If you miss a dose: Take it as soon as you remember, unless it is nearly time for your next dose. Never take two doses at once.
If you use too much: Contact your doctor, a poison control centre or your local emergency number straight away, even if you feel fine. Take the pack with you.
How to store it: Keep it in its original pack at room temperature (below 25°C / 77°F), away from heat, damp and direct sunlight. Do not use it after the expiry date.
- QWill I need to take Actoplus Met forever?
- A
Type 2 diabetes is usually a long-term condition, so most people keep taking their medicine. Healthy changes to diet, activity and weight can sometimes reduce how much you need.
- QHow will I know if Actoplus Met is working?
- A
Your doctor will check your blood sugar and HbA1c (an average of your blood sugar over about 3 months). Some people also check their sugar at home.
- QHow long does Actoplus Met take to work?
- A
It works slowly. It can take 2 to 3 months to see the full effect on blood sugar.

Amina Sokolov –
I liked that the site did not make things complicated. Service was courteous from start to finish. I would recommend this site to friends and family.
Daniel Ricci –
I used this site for my latest order and had no problems. No confusing steps, just a simple checkout. It arrived on time, just as I expected. The packaging was neat and secure.
Isabelle Mitchell –
Someone from the team followed up to make sure all was fine. And the quality looked good to me. Happy with the experience overall.
Diya Gill –
A friend told me about this site, so I gave it a go. Nothing was missing from my order. Thanks for making Actoplus Met so easy to order.
Ishaan Morris –
My experience with this order was good. For the price, I could not ask for more. Plus, the wrapping was solid, nothing shifted around in transit. Pleased with the whole thing.