Doxepin (Sinequan)
$0.27
Sinequan contains Doxepin and treats depression and anxiety, and in low doses is also used to help with sleep.
Drug Information
12 reviews for Doxepin (Sinequan)
Sinequan contains Doxepin.
Doxepin is a tricyclic antidepressant. At normal doses it treats depression and anxiety. In very low doses (3 mg to 6 mg), it is used to help people stay asleep.
What is it used for?
- Depression and anxiety
- Insomnia with trouble staying asleep (low dose)
- Itching (as a cream in some countries)
How does it work?
Doxepin raises levels of serotonin and noradrenaline in the brain to improve mood. It also blocks histamine, which is why it makes people sleepy.
This information is written in simple words to help you understand this product. It does not replace advice from your doctor or pharmacist.
Read these points before you start. If any of them apply to you, talk to your doctor or pharmacist first.
- Antidepressants can, rarely, cause thoughts of self-harm or suicide, especially in people under 25 and in the first few weeks. Tell someone close to you that you are taking it and ask them to tell you if they notice changes in your mood or behaviour.
- Do not take it with, or within 2 weeks of, an MAOI antidepressant (such as phenelzine or selegiline), or with linezolid or methylene blue.
- Taking it with other medicines that raise serotonin (other antidepressants, tramadol, triptans for migraine, lithium, St John's wort) can cause serotonin syndrome.
- It can raise the risk of bleeding, especially with aspirin, ibuprofen, naproxen or blood thinners.
- Tell your doctor if you have epilepsy, bipolar disorder or mania, glaucoma, heart problems, liver or kidney problems, or diabetes.
- Do not stop taking it suddenly. This can cause withdrawal symptoms like dizziness, electric-shock feelings, bad dreams and irritability. Your doctor will lower the dose slowly.
- It may make you sleepy or dizzy. Do not drive until you know how it affects you, and avoid alcohol.
- Tell your doctor if you are pregnant, planning a pregnancy or breastfeeding.
- Do not take it if you have recently had a heart attack or have heart rhythm problems. Tell your doctor about any heart disease.
- Tell your doctor if you have glaucoma, trouble passing urine, an enlarged prostate, constipation, an overactive thyroid or porphyria.
- An overdose can be very dangerous. Keep it out of the reach of children and others at risk.
- Tell your doctor or pharmacist about every other medicine, vitamin or herbal product you use.
- Keep this product out of the reach and sight of children.
Like all medicines, Sinequan can cause side effects, but not everybody gets them.
Common side effects
- Feeling sick (nausea), especially in the first 1 to 2 weeks
- Headache
- Trouble sleeping or feeling sleepy
- Sweating
- Dry mouth
- Lower sex drive, or trouble reaching orgasm or getting an erection
- Constipation
- Blurred vision
- Dizziness when standing up
- Weight gain
These are usually mild and often get better as your body gets used to it. Tell your doctor if they bother you or do not go away.
Stop using it and get medical help straight away if you notice:
- Thoughts of harming yourself or ending your life
- Feeling very high, overexcited or reckless (mania)
- Fever, sweating, shaking, muscle twitching, fast heartbeat and confusion (possible serotonin syndrome)
- A fit (seizure)
- Unusual bleeding or bruising, or black stools
- Confusion, headache and weakness, especially in older people (low sodium)
- A fast, pounding or uneven heartbeat, or fainting
- Being unable to pass urine
- Eye pain with blurred vision and red eye
This is not a complete list. If you notice anything unusual, ask your doctor or pharmacist.
- Take it once a day at bedtime, or in divided doses, as your doctor tells you.
- For depression, a common adult dose is 75 mg to 150 mg a day. For sleep, 3 mg to 6 mg is taken 30 minutes before bed.
- For sleep, do not take it within 3 hours of a meal, as food slows it down.
If you miss a dose: Take it as soon as you remember, unless it is nearly time for your next dose. Never take two doses at once.
If you use too much: Contact your doctor, a poison control centre or your local emergency number straight away, even if you feel fine. Take the pack with you.
How to store it: Keep it in its original pack at room temperature (below 25°C / 77°F), away from heat, damp and direct sunlight. Do not use it after the expiry date.
- QHow long does Sinequan take to work?
- A
Some people notice better sleep or energy in 1 to 2 weeks, but it usually takes 4 to 6 weeks to feel the full benefit on mood. Keep taking it even if you do not feel different straight away.
- QHow long will I need to take Sinequan?
- A
Most people take it for at least 6 months after they feel better, to stop the depression or anxiety coming back. Your doctor will review this with you.
- QCan I drink alcohol with Sinequan?
- A
It is best to avoid alcohol. It can make you more drowsy and can make depression and anxiety worse.
- QIs Sinequan addictive?
- A
No, antidepressants are not addictive. But stopping suddenly can cause withdrawal-like symptoms, so always reduce slowly with your doctor.

Nisha Eriksson –
I have ordered from here before and it went well again. It was cheaper than my usual place, and the service was just as good. I should add that everything I received was exactly what I ordered.
Mikhail Dlamini –
First time ordering Sinequan online and this site made it easy. I think the pricing is fair for what you get. No damage anywhere, the packaging did its job. Really happy with this order.
Amir Patterson –
I just received my order and wanted to leave a quick note. The customer team was respectful and answered everything I asked. Adding Sinequan to the cart and paying was quick.
Karim Youssef –
Here is my honest feedback on my order. Delivery was smooth with no surprises. The cost was clearly shown before I paid, so no nasty surprises. I had no trouble at checkout, which is not always the case on other sites. No problems at all, so I am pleased.
Grace Adeyemi –
I got my Sinequan here and the experience was easy. The packaging was neat and secure. On top of that, the total I saw at checkout was the total I paid. Nothing was missing from my order.
Emma Khalil –
I was a bit unsure at first, but ordering here worked out fine. Placing the order took only a few minutes. My Sinequan arrived on time, just as I expected.
Scarlett Joshi –
The Sinequan I got looked just like the listing. The parcel arrived a day or two sooner than I figured.
Sana Said –
I needed to place an order in a hurry and this site made it easy. I got the correct item the first time, with no mix-ups. I had a question about my Sinequan order and the support team replied fast. I was happy with how carefully it was packed. Simple, quick and reliable.
Tariq Mbeki –
The team kept me updated on my order status. Browsing the site was pleasant and the search worked well. Everything with my Sinequan was in order when I opened the box.
Henry Gutierrez –
Tried this site for the first time and had a good experience. Communication was good throughout the order. I found the cost to be better than what I saw elsewhere. I would order here again.
Amina Miller –
I placed my first order here and it went smoothly. It was what I expected when I opened it. Shipping was prompt and I got tracking updates along the way. I am satisfied and will come back for my next order.
Karim Khalil –
Writing this after my latest order from the site. The order arrived without any hold-ups. The quantity was right and everything was accounted for.