Amitriptyline (Endep)
$0.35
Endep contains Amitriptyline and is used for depression, nerve pain and to help with sleep difficulties.
Drug Information
15 reviews for Amitriptyline (Endep)
Endep contains Amitriptyline.
Amitriptyline is a tricyclic antidepressant. In higher doses it treats depression. In much lower doses it is widely used for nerve pain, preventing migraine and headaches, and helping with sleep when pain keeps you awake.
What is it used for?
- Nerve pain (for example after shingles, or from diabetes)
- Preventing migraine and tension headaches
- Depression (higher doses)
- Long-term pain such as fibromyalgia
How does it work?
Amitriptyline raises the levels of serotonin and noradrenaline in the brain and spinal cord. At low doses, this calms pain signals from nerves. At higher doses, it improves mood.
This information is written in simple words to help you understand this product. It does not replace advice from your doctor or pharmacist.
Read these points before you start. If any of them apply to you, talk to your doctor or pharmacist first.
- Antidepressants can, rarely, cause thoughts of self-harm or suicide, especially in people under 25 and in the first few weeks. Tell someone close to you that you are taking it and ask them to tell you if they notice changes in your mood or behaviour.
- Do not take it with, or within 2 weeks of, an MAOI antidepressant (such as phenelzine or selegiline), or with linezolid or methylene blue.
- Taking it with other medicines that raise serotonin (other antidepressants, tramadol, triptans for migraine, lithium, St John's wort) can cause serotonin syndrome.
- It can raise the risk of bleeding, especially with aspirin, ibuprofen, naproxen or blood thinners.
- Tell your doctor if you have epilepsy, bipolar disorder or mania, glaucoma, heart problems, liver or kidney problems, or diabetes.
- Do not stop taking it suddenly. This can cause withdrawal symptoms like dizziness, electric-shock feelings, bad dreams and irritability. Your doctor will lower the dose slowly.
- It may make you sleepy or dizzy. Do not drive until you know how it affects you, and avoid alcohol.
- Tell your doctor if you are pregnant, planning a pregnancy or breastfeeding.
- Do not take it if you have recently had a heart attack or have heart rhythm problems. Tell your doctor about any heart disease.
- Tell your doctor if you have glaucoma, trouble passing urine, an enlarged prostate, constipation, an overactive thyroid or porphyria.
- An overdose can be very dangerous. Keep it out of the reach of children and others at risk.
- Tell your doctor or pharmacist about every other medicine, vitamin or herbal product you use.
- Keep this product out of the reach and sight of children.
Like all medicines, Endep can cause side effects, but not everybody gets them.
Common side effects
- Feeling sick (nausea), especially in the first 1 to 2 weeks
- Headache
- Trouble sleeping or feeling sleepy
- Sweating
- Dry mouth
- Lower sex drive, or trouble reaching orgasm or getting an erection
- Constipation
- Blurred vision
- Dizziness when standing up
- Weight gain
These are usually mild and often get better as your body gets used to it. Tell your doctor if they bother you or do not go away.
Stop using it and get medical help straight away if you notice:
- Thoughts of harming yourself or ending your life
- Feeling very high, overexcited or reckless (mania)
- Fever, sweating, shaking, muscle twitching, fast heartbeat and confusion (possible serotonin syndrome)
- A fit (seizure)
- Unusual bleeding or bruising, or black stools
- Confusion, headache and weakness, especially in older people (low sodium)
- A fast, pounding or uneven heartbeat, or fainting
- Being unable to pass urine
- Eye pain with blurred vision and red eye
This is not a complete list. If you notice anything unusual, ask your doctor or pharmacist.
- Take it once a day, in the evening or at bedtime, because it often makes you sleepy.
- Swallow the tablet with water. You can take it with or without food.
- For pain or migraine, a common dose is 10 mg at night, slowly raised to 25 mg to 75 mg. For depression, higher doses are used.
- It can take a few weeks to feel the full effect on pain.
If you miss a dose: Take it as soon as you remember, unless it is nearly time for your next dose. Never take two doses at once.
If you use too much: Contact your doctor, a poison control centre or your local emergency number straight away, even if you feel fine. Take the pack with you.
How to store it: Keep it in its original pack at room temperature (below 25°C / 77°F), away from heat, damp and direct sunlight. Do not use it after the expiry date.
- QHow long does Endep take to work?
- A
Some people notice better sleep or energy in 1 to 2 weeks, but it usually takes 4 to 6 weeks to feel the full benefit on mood. Keep taking it even if you do not feel different straight away.
- QHow long will I need to take Endep?
- A
Most people take it for at least 6 months after they feel better, to stop the depression or anxiety coming back. Your doctor will review this with you.
- QCan I drink alcohol with Endep?
- A
It is best to avoid alcohol. It can make you more drowsy and can make depression and anxiety worse.
- QIs Endep addictive?
- A
No, antidepressants are not addictive. But stopping suddenly can cause withdrawal-like symptoms, so always reduce slowly with your doctor.
- QWhy take Endep at night?
- A
It often makes people drowsy, so taking it at bedtime can help you sleep and reduces daytime sleepiness.
- QI don't have depression. Why was I given Endep?
- A
At low doses, amitriptyline is a common treatment for nerve pain and headaches. It does not mean your doctor thinks you are depressed.

Olivia Ibrahim –
I decided to try this site and it turned out well. The delivery took about as long as I was told. The price was fair compared to other places I checked. Easy to order Endep here, and I will do it again.
Kavya Petrov –
I have ordered from here before and it went well again. I found Amitriptyline on the site quickly and checkout was simple. Everything was packed carefully and nothing was damaged. I would recommend this site to friends and family.
Alice Cooper –
The support staff were quick to respond and easy to deal with. Besides that, packed properly, with nothing out of place. Everything with my Amitriptyline was in order when I opened the box.
Mason Miller –
Quick review of my recent order. The Endep was priced fairly compared to other sites. The product matched the description on the page. Checkout was simple and I never felt lost on the site. A good experience from start to finish.
Samuel Keller –
I have ordered Amitriptyline here before and this time was just as smooth. The wrapping was solid, nothing shifted around in transit. Support was friendly and cleared up my doubt quickly. Another good thing: tracking worked well and the delivery went exactly as planned.
Shreya Ross –
I found Amitriptyline on this site pretty quickly. The confirmation emails were clear and arrived quickly. Good, careful packing with no dents or tears. Would not hesitate to use this site again.
Alessandro Adams –
Placed an order for Amitriptyline and it was handled well. The packing was discreet and tidy. It came in a reasonable amount of time. Everything went well, so I will be back.
Sameer Liu –
My order went through without any problems. Live chat was handy and the answers were useful. Prices here are easy on the pocket. I am satisfied and will come back for my next order.
Jun Nelson –
A friend told me about this site, so I gave it a go. It was cheaper than my usual place, and the service was just as good. Nothing was broken or leaking and the box was in good shape.
Chinedu Okeke –
Here is my honest feedback on my order. Delivery was smooth with no surprises. I reached out with a small query and it was sorted straight away.
Chloe Mensah –
Got it faster than I was expecting, which was nice. The team kept me updated on the status of my Amitriptyline order. Everything I received was exactly what I ordered. Nothing negative to say, it was a good one.
Katarina Jimenez –
Wanted to share my experience with this order. Delivery of my Amitriptyline was quicker than I thought it would be. I should add that for the price, I could not ask for more. It was a pleasant experience and I am glad I chose this site.
Marta Yang –
My experience with this order was good. The listing was easy to understand and nothing felt confusing. On top of that, the packaging was neat and secure. Simple, quick and reliable.
Irina Nakamura –
I placed an order last week and it was handled well. The quantity was right and everything was accounted for. Placing the order took only a few minutes. Thanks for the easy experience!
Anthony Tran –
Picked up my Amitriptyline from this site and I am glad I did. The cost was clearly shown before I paid, so no nasty surprises.