Divalproex Sodium (Depakote)
$0.73
Depakote (Divalproex sodium) controls seizures in epilepsy, stabilises mood in bipolar disorder and helps prevent migraines.
Drug Information
9 reviews for Divalproex Sodium (Depakote)
Depakote contains Divalproex Sodium.
Divalproex sodium (a form of valproate) is used to control seizures in epilepsy, to treat mania in bipolar disorder, and to help prevent migraines.
It must not be used by girls or women who could get pregnant unless no other treatment works and they follow a pregnancy prevention programme, because it can seriously harm an unborn baby.
What is it used for?
- Epilepsy (many types of seizures)
- Mania in bipolar disorder
- Preventing migraine headaches
How does it work?
Divalproex increases a calming brain chemical called GABA and steadies nerve signals, which helps prevent seizures and stabilises mood.
This information is written in simple words to help you understand this product. It does not replace advice from your doctor or pharmacist.
Read these points before you start. If any of them apply to you, talk to your doctor or pharmacist first.
- Do not stop taking it suddenly, even if you feel well. This can bring on seizures. Your doctor will lower the dose slowly if you need to stop.
- A small number of people taking seizure medicines have thoughts of self-harm. Tell your doctor straight away if you notice changes in your mood.
- It can make you sleepy or dizzy. Do not drive until you know how it affects you, and follow the driving rules for epilepsy in your country.
- Alcohol can make drowsiness worse and may make seizures more likely.
- Tell your doctor if you are pregnant, planning a pregnancy or breastfeeding. Some seizure medicines can harm an unborn baby, but stopping suddenly can also be dangerous.
- Tell your doctor if you have liver or kidney problems.
- Valproate can cause serious birth defects and learning problems in babies. Women who could get pregnant must use effective contraception and see their doctor regularly.
- It can rarely cause serious liver damage or pancreatitis, especially in the first 6 months. You will need blood tests.
- Tell your doctor if you have a mitochondrial disorder or a urea cycle disorder.
- Tell your doctor or pharmacist about every other medicine, vitamin or herbal product you use.
- Keep this product out of the reach and sight of children.
Like all medicines, Depakote can cause side effects, but not everybody gets them.
Common side effects
- Feeling sleepy or tired
- Dizziness or feeling unsteady
- Headache
- Feeling sick
- Weight gain and increased appetite
- Shaking (tremor)
- Temporary hair thinning
These are usually mild and often get better as your body gets used to it. Tell your doctor if they bother you or do not go away.
Stop using it and get medical help straight away if you notice:
- Thoughts of harming yourself, or sudden changes in mood or behaviour
- A severe skin rash, especially with blisters, peeling, mouth sores or fever
- Seizures that are more frequent or last longer
- Fever, swollen glands and feeling unwell (a rare allergic reaction)
- Yellowing of the skin or eyes, severe tiredness, being sick or loss of seizure control (liver problems)
- Severe stomach pain that spreads to the back (pancreatitis)
- Unusual bruising or bleeding
This is not a complete list. If you notice anything unusual, ask your doctor or pharmacist.
- Take it 1 to 3 times a day, with food, as your doctor tells you.
- Swallow the tablet whole. Do not crush or chew it.
- A common adult dose for epilepsy is 10 mg to 15 mg per kilogram of body weight per day, increased slowly. For migraine, a common dose is 250 mg twice a day or 500 mg once a day (extended-release).
- Go to all your blood tests.
If you miss a dose: Take it as soon as you remember, unless it is nearly time for your next dose. Never take two doses at once.
If you use too much: Contact your doctor, a poison control centre or your local emergency number straight away, even if you feel fine. Take the pack with you.
How to store it: Keep it in its original pack at room temperature (below 25°C / 77°F), away from heat, damp and direct sunlight. Do not use it after the expiry date.
- QCan I stop Depakote if I have not had a seizure for a long time?
- A
Only with your doctor's advice. Stopping suddenly can bring seizures back. If stopping is right for you, it will be done slowly.
- QCan I drink alcohol with Depakote?
- A
It is best to avoid or strictly limit alcohol. It can make you more drowsy and may trigger seizures.
- QCan I drive while taking Depakote?
- A
It depends on your seizure control and local driving rules. Ask your doctor.

Carolina Farah –
I got a helpful reply when I asked about my order. Adding Divalproex Sodium to the cart and paying was quick.
Dmitri Collins –
The quality looked good to me. The Divalproex Sodium was priced fairly compared to other sites. Would not hesitate to use this site again.
Louis Phillips –
My Depakote order went through without a hitch. No complaints about the product. Pricing was reasonable and there were no hidden charges. Overall, a smooth and simple experience.
Luca Traore –
Checkout was simple and I never felt lost on the site. Everything inside was snug and protected. The support staff were quick to respond and easy to deal with. Easy to deal with, which is what I wanted.
Lin Cooper –
My order went through without any problems. I found Depakote on the site quickly and checkout was simple.
Alice Rivera –
My experience with this order was good. The quantity was right and everything was accounted for. The team kept me updated on the status of my Divalproex Sodium order. I am satisfied and will come back for my next order.
Aditi Brown –
The whole ordering process felt easy and well organised. I could follow the shipment and it arrived as scheduled. I will be ordering Depakote from here again.
Meera Ibrahim –
Ordering from this site was easy. I checked everything against my order and it was all correct. The price was fair compared to other places I checked. I would order Depakote here again.
Hassan Anderson –
I received everything in good time. I had a question about my Divalproex Sodium order and the support team replied fast. Another good thing: for the price, I could not ask for more.