Levodopa + Carbidopa (Sinemet)
$0.84
Sinemet combines Levodopa and Carbidopa to improve movement, stiffness and tremor in Parkinson’s disease.
Drug Information
13 reviews for Levodopa + Carbidopa (Sinemet)
Sinemet contains two medicines, levodopa and carbidopa. It is the most effective medicine for the movement symptoms of Parkinson's disease, such as slowness, stiffness and shaking.
What is it used for?
- Parkinson's disease
How does it work?
Parkinson's disease happens when brain cells that make dopamine are lost. Levodopa is turned into dopamine in the brain. Carbidopa stops levodopa being broken down in the rest of the body, so more reaches the brain and there is less sickness.
This information is written in simple words to help you understand this product. It does not replace advice from your doctor or pharmacist.
Read these points before you start. If any of them apply to you, talk to your doctor or pharmacist first.
- Do not take it if you have narrow-angle glaucoma, a skin cancer called melanoma (or unexplained skin spots), or take an MAOI antidepressant.
- High-protein meals can reduce how well it works. Your doctor may suggest spreading protein through the day.
- It can make you suddenly fall asleep during daily activities. Do not drive if this happens.
- Some people develop strong urges to gamble, shop, eat or have sex. Tell your doctor if you or your family notice this.
- Do not stop taking it suddenly, as this can cause a serious reaction with fever and stiffness.
- Iron tablets can reduce absorption. Take them at a different time.
- Tell your doctor or pharmacist about every other medicine, vitamin or herbal product you use.
- Keep this product out of the reach and sight of children.
Like all medicines, Sinemet can cause side effects, but not everybody gets them.
Common side effects
- Feeling sick, especially at first
- Dizziness when standing up
- Loss of appetite
- Sleepiness
- Uncontrolled twisting or jerking movements (dyskinesia) after long use
- Dark urine, sweat or saliva (harmless)
These are usually mild and often get better as your body gets used to it. Tell your doctor if they bother you or do not go away.
Stop using it and get medical help straight away if you notice:
- Falling asleep suddenly without warning
- Seeing or hearing things that are not there, or feeling very confused
- Strong, hard-to-control urges to gamble, shop or eat
- High fever and stiff muscles after stopping or reducing the dose
This is not a complete list. If you notice anything unusual, ask your doctor or pharmacist.
- Take it 3 or 4 times a day (or as your doctor tells you), spacing doses evenly.
- Taking it 30 minutes before meals helps it work best. If it makes you feel sick, take it with a small low-protein snack.
- Your doctor will start low and adjust the dose to control your symptoms.
- Swallow controlled-release tablets whole or halved. Do not crush or chew them.
If you miss a dose: Take it as soon as you remember, unless it is nearly time for your next dose. Never take two doses at once.
If you use too much: Contact your doctor, a poison control centre or your local emergency number straight away, even if you feel fine. Take the pack with you.
How to store it: Keep it in its original pack at room temperature (below 25°C / 77°F), away from heat, damp and direct sunlight. Do not use it after the expiry date.
- QWhy does protein affect Sinemet?
- A
Protein and levodopa use the same pathway to get from the gut to the brain. A big protein meal can block levodopa and make it work less well.
- QWhat are "on" and "off" periods?
- A
After some years, the effect of each dose may wear off before the next one. Your doctor can change the timing or add other medicines.
- QWhy is my urine dark on Sinemet?
- A
It can darken urine, sweat and saliva. This is harmless.

Santiago Shin –
My experience with this order was good. Everything was in order when I opened the box. The listing was easy to understand and nothing felt confusing. I would recommend this site to friends and family.
Anika Campbell –
Here is my honest feedback on my order. What arrived was just as listed on the site. The whole ordering process felt easy and well organised.
Dalia Phillips –
I was a bit unsure at first, but ordering here worked out fine. My Sinemet matched the description on the page.
Amelie Weber –
Ordered Sinemet a few days ago and wanted to leave a quick review. I got my order placed in no time.
Elena Johansson –
I ordered from here after comparing a few options. I found Sinemet on the site quickly and checkout was simple. I found the cost to be better than what I saw elsewhere. Pleased with the whole thing.
Andrew Gonzalez –
Tried this site for the first time and had a good experience. It was cheaper than my usual place, and the service was just as good. Navigation is simple, even for someone who is not great with websites. Plus, the courier delivered it safely and on schedule. Would happily recommend it.
Nikolai Johnson –
Everything with my Sinemet was in order when I opened the box. No surprise fees at checkout, which I appreciated. And someone from the team followed up to make sure all was fine. Solid experience, nothing to complain about.
Hussein Lewis –
My Sinemet came well wrapped and in perfect condition. Five stars from me. I got a helpful reply when I asked about my order.
Marco Dubois –
Ordering from this site was easy. I think the pricing is fair for what you get. Nothing was broken or leaking and the box was in good shape.
Sanjay Moreau –
I used this site for my latest order and had no problems. The product matched the description on the page. I did not have to hunt around, the item was listed right where I expected. Happy with the experience overall.
Mariam Allen –
I decided to try this site and it turned out well. Ordering was straightforward from start to finish. The item looked exactly like the listing. Good service, will reorder when I need to.
Katarina Mbeki –
Quick review of my recent order. The expiry date was fine and everything looked as it should. The support staff were quick to respond and easy to deal with. I am glad I tried this site.
Tariq Henderson –
Communication was good throughout the order. Honestly, everything on the product page was clear, so I knew what I was getting. Overall very good, thanks.