Eplerenone (Inspra)
$1.00
Inspra (Eplerenone) treats heart failure after a heart attack and lowers high blood pressure by blocking the hormone aldosterone.
Drug Information
1 review for Eplerenone (Inspra)
Inspra contains Eplerenone.
Eplerenone is a medicine that blocks a hormone called aldosterone. It is used for heart failure, especially after a heart attack, and for high blood pressure.
It works like spironolactone but is less likely to cause breast swelling or hormone side effects.
What is it used for?
- Heart failure after a heart attack
- Long-term heart failure with a weak heart pump
- High blood pressure
How does it work?
Aldosterone makes the body hold on to salt and water and can cause scarring of the heart. Eplerenone blocks this hormone, which helps the heart and lowers blood pressure.
This information is written in simple words to help you understand this product. It does not replace advice from your doctor or pharmacist.
Read these points before you start. If any of them apply to you, talk to your doctor or pharmacist first.
- High blood pressure usually has no symptoms, so keep taking your medicine even when you feel well. Stopping can make your blood pressure rise again.
- It can make you feel dizzy, especially when you stand up quickly or when you first start. Get up slowly from sitting or lying down.
- Alcohol can make dizziness worse and raise blood pressure over time. Keep it to small amounts.
- Tell your doctor if you have kidney or liver problems.
- Have your blood pressure checked regularly, as your doctor advises.
- Tell your doctor if you have gout, diabetes, kidney or liver problems.
- It can change the levels of salts such as potassium and sodium in your blood. Your doctor may do blood tests.
- Drink enough fluid, especially in hot weather or if you are sick or have diarrhoea, to avoid becoming dehydrated.
- It can raise potassium to dangerous levels. Do not take potassium supplements or salt substitutes, and your doctor will check your potassium regularly.
- Do not take it with strong "blocking" medicines like ketoconazole, itraconazole, clarithromycin or ritonavir.
- Tell your doctor or pharmacist about every other medicine, vitamin or herbal product you use.
- Keep this product out of the reach and sight of children.
Like all medicines, Inspra can cause side effects, but not everybody gets them.
Common side effects
- Dizziness
- Diarrhoea or feeling sick
- High potassium levels on blood tests
These are usually mild and often get better as your body gets used to it. Tell your doctor if they bother you or do not go away.
Stop using it and get medical help straight away if you notice:
- Fainting, or feeling like you are going to faint
- Swelling of the face, lips, tongue or throat, or trouble breathing or swallowing
- Muscle cramps, weakness, confusion or an uneven heartbeat (possible salt or potassium problems)
- Very little urine, extreme thirst or feeling very dizzy (dehydration)
- Muscle weakness, tingling, or a slow or uneven heartbeat (high potassium)
This is not a complete list. If you notice anything unusual, ask your doctor or pharmacist.
- Take it once a day, at the same time each day. You can take it with or without food.
- A common adult dose is 25 mg once a day, raised to 50 mg after about 4 weeks.
- Go to all your blood tests.
- Swallow the tablet with a glass of water.
If you miss a dose: Take it as soon as you remember the same day. If it is nearly time for your next dose, skip the missed one. Never take two doses at once.
If you use too much: Contact your doctor, a poison control centre or your local emergency number straight away, even if you feel fine. Take the pack with you.
How to store it: Keep it in its original pack at room temperature (below 25°C / 77°F), away from heat, damp and direct sunlight. Do not use it after the expiry date.
- QDo I need to take Inspra for the rest of my life?
- A
Often, yes. High blood pressure is usually a long-term condition. Your doctor will review your treatment over time. Do not stop without talking to them.
- QCan I drink alcohol with Inspra?
- A
Small amounts are usually fine, but alcohol can make you dizzy and can raise your blood pressure. Try to keep within safe limits.
- QWhat else can help my blood pressure?
- A
Eating less salt, staying active, keeping a healthy weight, not smoking and cutting down on alcohol all help your medicine work better.
- QWhat is the best time to take Inspra?
- A
In the morning. If you need a second dose, take it no later than mid-afternoon, so you are not woken at night to pass urine.

Anika Mehta –
I needed Eplerenone and this was the easiest place I found to order it. Service was courteous from start to finish. It was affordable and the total at checkout matched what I expected. Everything went well, so I will be back.